At Asé Pure Naturals, we understand that your health is your greatest asset. Your ability to perform at your best — physically, mentally, and spiritually — depends on more than just effort; it requires nurturing the very cells that make up your body. That’s why maintaining optimal cellular function is non-negotiable. This is where NAD+ (Nicotinamide Adenine Dinucleotide) comes in — a powerful molecule that’s not just essential for energy, brain function, and overall health, but also for helping you live life with vitality and resilience. Without it, our bodies struggle to perform at their peak, and the effects of aging and disease can catch up faster than we’d like. It’s not just about feeling good today; it’s about building a foundation for a healthier, longer future.

How NAD+ Levels Are Depleted

It’s important to understand that NAD+ depletion is not only caused by aging, but also by various lifestyle factors, environmental toxins, and medication use. Every day, our NAD+ levels can be depleted by:

• Age: As we age, the body’s ability to naturally produce NAD+ declines, leading to reduced cellular repair and increased inflammation.
  • Environmental Toxins: Exposure to pollutants, pesticides, and chemicals in the food system can trigger oxidative stress, accelerating NAD+ depletion.
  • Poor Diet: A diet high in processed foods and low in essential nutrients can hinder NAD+ production. A nutrient-deficient diet also prevents the body from maintaining its energy levels, contributing to fatigue.
  • Illness: Chronic conditions such as diabetes, cardiovascular diseases, and autoimmune disorders can drain NAD+ reserves by increasing inflammation in the body.
  • Addiction and Substance Use: Drugs, including alcohol, nicotine, and opioids, can significantly lower NAD+ levels by causing oxidative stress and damage to mitochondria. Addiction is not the only culprit, though — stimulant medications, including those for attention disorders, can also contribute to NAD+ depletion. By increasing neurotransmitter release, stimulants elevate oxidative stress and inhibit the body’s ability to regenerate NAD+ over time.

How Opioids and Other Addictive Substances Impact NAD+

• Opioids: Chronic opioid use and addiction can negatively affect NAD+ metabolism. Opioid abuse often leads to oxidative stress and inflammation, which depletes NAD+. This happens because the body’s repair mechanisms, including those involving NAD+, become overwhelmed by the damage caused by long-term opioid use. Additionally, opioids interfere with dopamine production and neuroplasticity, both of which require NAD+ for optimal functioning.
  • Opioid-induced neurodegeneration: Prolonged use of opioids can cause significant neuronal damage, disrupting the normal functioning of brain pathways that rely on NAD+. This is why NAD+ therapy is often used in addiction recovery programs to help restore brain health, improve neuroplasticity, and support dopamine systems.
  • Other Addictive Drugs: Drugs like alcohol, stimulants, and even nicotine can also interfere with NAD+ metabolism and reduce NAD+ levels. These substances increase oxidative stress and inflammation in the body, which depletes NAD+ and hampers its restorative functions.

How Medications Impact NAD+ Levels

Some long-term medications, such as cholesterol-lowering drugs, diabetes medications, and non-steroidal anti-inflammatory drugs (NSAIDs), can also affect NAD+ levels either directly or indirectly:

• Cholesterol-lowering drugs: These are known to inhibit the mevalonate pathway, which is involved in cholesterol synthesis. This pathway also plays a role in the production of coenzyme Q10 (CoQ10), an important molecule for cellular energy production and NAD+ regeneration. By inhibiting this pathway, these drugs can indirectly decrease the body’s ability to regenerate NAD+, contributing to fatigue and other symptoms associated with long-term use.
  • Diabetes Medications: Certain diabetes medications, particularly those used for managing glucose levels, have been shown to influence cellular metabolism. Some of these medications can activate pathways that affect NAD+ levels by influencing cellular energy balance. However, over the long term, they can contribute to a decline in NAD+ if used with other medications or underlying conditions.
  • NSAIDs (Non-Steroidal Anti-Inflammatory Drugs): Long-term use of NSAIDs may not directly decrease NAD+ levels, but they can increase oxidative stress and inflammation. Chronic inflammation is a major factor in NAD+ depletion because it accelerates cellular damage, which can overwhelm the body’s NAD+ repair mechanisms. This may indirectly lead to lower NAD+ levels over time.

How IV NAD+ Therapy and Supplementation Support Your Health

• Immediate Boost with IV Therapy:
  IV NAD+ therapy offers rapid benefits in energy, brain function, and cellular health. Many local clinics, typically run by doctors or ER nurses, offer this on a walk-in or appointment basis. Though not typically covered by insurance, it can be a game-changer for long-term health and longevity.
• IV NAD+ Therapy:
  IV therapy is one of the fastest ways to elevate NAD+ levels by directly infusing it into your bloodstream, bypassing digestion for immediate benefits. This is especially helpful for those recovering from addiction or seeking cellular rejuvenation. Results are quick, impactful, and support both physical and mental health.
• NAD+ Supplementation:
  After an initial IV session, maintaining NAD+ levels through supplementation, such as TruNiagen, is effective for long-term support. TruNiagen provides nicotinamide riboside (NR), a precursor to NAD+, helping the body naturally produce NAD+ over time.
• Combine IV Therapy with TruNiagen:
  For the fastest results, combine an IV drip with daily TruNiagen supplementation. The IV drip gives a quick boost, while TruNiagen helps sustain NAD+ levels for long-term health.
• TruNiagen for Long-Term Maintenance:
  Studies show that taking TruNiagen daily can boost NAD+ levels in as little as three weeks. As a precursor, it encourages your body to produce its own NAD+, making it an affordable, effective solution for overall health, clarity, and performance.
• Maintenance with Periodic IV Therapy:
  Depending on your lifestyle and health needs, periodic IV therapy may be beneficial, alongside daily TruNiagen supplementation. Discuss with your healthcare provider to determine the best approach for you.

The Power of CBD for Long-Term Health and Wellness

CBD, or cannabidiol, is increasingly recognized for its wide array of health benefits, particularly its neuroprotective properties and ability to promote neurogenesis. Unlike many conventional pain relievers, CBD works with your body’s natural systems to support long-term health, rather than offering only temporary relief. This makes it an exceptional alternative to more toxic pain management methods, which can lead to long-term brain health, organ damage and other side effects.

One of CBD’s most compelling qualities is its ability to combat oxidative stress. As a powerful antioxidant, CBD helps reduce the damage caused by free radicals, which are linked to aging and various chronic conditions. By lowering oxidative stress, CBD supports the health of your cells and tissues, including those in the brain, where oxidative damage can impair cognitive function and accelerate neurodegenerative diseases. Our CBD Extracts for Stress and Brain Support are designed to enhance your mental clarity and cognitive function, helping you stay sharp in your day-to-day activities.

CBD is also highly effective at regulating cortisol levels, which can help reduce chronic stress and improve overall mood. Chronic stress is not only harmful to mental health but can also elevate inflammation in the body, contributing to a wide range of conditions from joint pain to autoimmune disorders. By keeping cortisol levels in check, CBD supports a balanced stress response, which is crucial for long-term health. Our CBD Softgels for Sleep are an excellent tool to help manage this stress while also encouraging deeper, more restorative rest for a better, more relaxed state of mind.

In addition, CBD has been shown to promote better sleep by addressing factors that disrupt rest, such as pain, stress, and anxiety. A good night’s sleep is essential for both physical recovery and mental clarity, and CBD’s calming effects make it a natural sleep aid, offering deeper and more restorative rest. Our Recharge with Sleep Softgels, with their targeted 30mg of CBD per serving, are specially formulated to support your sleep needs, ensuring you wake up feeling refreshed and ready to take on the day.

When it comes to pain and inflammation, CBD is a powerful anti-inflammatory agent. It targets the root causes of discomfort, such as joint pain, muscle soreness, and nerve pain, without the harmful side effects of traditional painkillers. This makes it an ideal option for people seeking to manage chronic pain or inflammation naturally and safely. Our CBD Topicals provide targeted relief where you need it most, offering a soothing and effective way to combat pain and inflammation.

CBD isn’t just a temporary fix; it offers cumulative, long-term benefits that support ongoing brain health, emotional well-being, and overall vitality. Its neuroprotective properties help safeguard brain function, reduce cognitive decline, and support neurogenesis, making it a vital part of a comprehensive health regimen.

The Ultimate Powerhouse: CBD + NAD+

When combined with NAD+ support, CBD becomes even more of a powerhouse for long-term health. While CBD supports your brain, reduces inflammation, and combats oxidative stress, NAD+ plays a crucial role in cellular energy production and repair. Together, these two compounds offer a holistic approach to wellness — from protecting the brain to supporting the body’s natural repair processes. This powerful combination helps promote sustained vitality, cognitive function, and overall health.

CBD, known for its anti-inflammatory and neuroprotective properties, can further support NAD+ levels. Studies show that CBD can help reduce oxidative stress, regulate inflammation, and promote mitochondrial health — all of which contribute to maintaining healthy NAD+ levels. By combining CBD with NAD+ support, you’re giving your body the best opportunity for longevity and optimal brain function.

The Role of NAD+ in Addiction Recovery

While recreational drug use and addiction have a direct effect on NAD+ levels, it’s important to note that prescription medications, such as opioids, alcohol, stimulants, and even nicotine, can also play a detrimental role. These substances lead to increased oxidative stress, inflammation, and mitochondrial dysfunction, all of which contribute to lower NAD+ levels.

Restoring NAD+ levels is critical in addiction recovery, not only to replenish energy but also to promote neurogenesis — the process of regenerating new neurons in the brain. NAD+ therapy, in particular, has gained attention for its ability to help those recovering from addiction by reducing cravings and supporting brain health. Immediate increases in NAD+ levels, achieved through IV therapy, are often used to jumpstart recovery processes. Supplementing with products afterward ensures that NAD+ remains at optimal levels, supporting long-term recovery and longevity.

Why NAD+ is Essential for Everyone — Not Just Athletes

While athletes and high performing individuals as well as those recovering from addiction may benefit greatly from NAD+ supplementation, it’s important to recognize that NAD+ is vital for everyone. Whether you’re focused on performing at your best in work, maintaining cognitive function as you age, or supporting your body in the fight against chronic illness, keeping your NAD+ levels high is crucial. The best way to get started is with a combination of IV NAD+ therapy for an immediate boost, followed by supplementation to keep your levels optimal for long-term health and performance.

At Asé Pure Naturals, we’re committed to helping you live your healthiest life. By supporting your body’s natural processes with safe, effective supplements and utilizing therapies like IV NAD+, we believe you can achieve the longevity, vitality, and mental clarity you deserve. Take control of your health, restore balance to your cells, and start performing at your best today.

Disclaimer: The information provided in this blog is for educational purposes only and is not intended as medical advice. Always consult with a healthcare professional before making any changes to your health routine or treatment plan.